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Positive Real-World Data for Naloxone Nasal Spray

Adapt Pharma's naloxone nasal spray (Narcan) has been working well in the real world, reversing the vast majority of opioid overdoses for which it's deployed, researchers reported here.

In a survey of a small number of community organizations that used the 4-mg nasal spray, first responders were successful at reviving about 98% of cases who went on to survive, George Avetian, DO, senior medical advisor to Delaware County in Pennsylvania, and colleagues reported at the American Academy of Pain Medicine meeting here.

Community groups have been eager for real-world data, as only pharmacokinetic and usability data were needed for FDA approval of Adapt's product. The company conducted the survey ahead of an October FDA advisory committee that was tasked with examining whether naloxone dosing standards needed to be raised. (The panel was divided.)

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